From the Bax Group at the National Institutes of Health ...
MICS Server:
Prediction of Protein Helix Capping Motifs and Beta-turns from Chemical Shifts

As described in the paper:
Identification of helix capping motifs and beta-turns from NMR chemical shifts
Yang Shen, and Ad Bax. J. Biomol. NMR, 52, 211-232 (2012)

MICS Software Web Site: http://spin.niddk.nih.gov/bax/software/MICS

Contacts: shenYang@niddk.nih.gov ; bax@nih.gov

The MICS results can be viewed with the Web-Based Java Version of the RAMA+ Viewer:


Chemical Shift Input

The input table of chemical shifts and sequence information. The format of the table is described in the TALOS Web Page. Example: ubiq.tab

As an alternative, the input table of chemical shifts and sequence information can be specified as a BMRB NMR-Star format file. In order to use NMR-Star format as input, the BMRB file should have chemical shift information and complete sequence information for a single protein only. When input is supplied as a BMRB file, CYS residues with a CB shift of 34ppm or less are assumed to be reduced, and HIS residues in tables with a listed pH of 6.0 or less are assumed to be protonated. Example: ubiq.str
(Click here to see a complete list and description of all allowed formats.)

Prediction Options

Apply Offset Correction Select this option to test the input chemical shift referencing and apply an automated offset correction if needed.
Apply Deuterium Correction (Deuterated Proteins Only) Select this option if the input CA and CB chemical shifts need to be adjusted for deuterium isotope effect. Leave this option off if you have already adjusted the CA and CB shifts.

Submission Details

Calculation results will be sent via Email only
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last update: June 2 2012