Solution structure of the complete 44 kDa ectodomain of SIV gp41 and design of a chimeric protein, NCCG-gp41 that inhibits HIV-Env mediated fusion

 

Diagram of HIV-env mediated cell fusion and solution structure of the complete 44 kDa ectodomain of SIV gp41

gp41

 

Design of the HIV-Env mediated fusion inhibitor NCCG-gp41

gp41 inhibitor design

 

Inhibition of HIV-Env mediated cell fusion by NCCG-gp41, and the C34 and N36 peptides

inhibition of hiv fusion

 

Caffrey, M., Cai, M., Kaufman, J., Stahl, S.J., Wingfield, P.T., Covell, D.G., Gronenborn, A.M. & Clore, G.M. (1998) Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J. 17, 4572-4584. pubmed PDF

Louis, J.M., Bewley, C.A. & Clore, G.M. (2001) Design and properties of NCCG-gp41, a chimeric gp41 molecule with nanomolar HIV-fusion inhibitory activity. J. Biol. Chem. 276, 29485-29489. pubmed PDF

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