Structural basis for SRY-dependent 46-X,Y sex reversal: Modulation of DNA bending by the naturally occuring M9I mutation

 

Overall comparison of wild type SRY (red) and M9I SRY-DNA complexes

structures

Comparison of DNA in wild type (red with green DNA axis) and M9I (blue with yellow DNA axis) SRY-DNA complex

comparison of wild type and m9i mutant dna

Comparison of surfaces of wild type (a and b) and M9I (c and d) SRY-DNA complexes

comparison of wild type and m9i surfaces

Detailed views of contacts involving M9 in wild type and I9 in M9I mutant SRY-DNA complexes

detailed protein-dna contacts

Werner, M.H., Huth, J.R., Gronenborn, A.M. & Clore, G.M. (1995) Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex. Cell 81, 705-714. pubmed

Murphy, E.C., Zhurkin, V.B., Louis, J.M., Cornilescu, G. and Clore, G.M. (2001) Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occuring point mutation. J. Mol. Biol. 312, 481-499. pubmed PDF

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