Highly Cited Publications

h-index: 117 from Web of Science (Institute for Scientific Information) and 129 from Google Scholar (the h index is defined as the number of papers h that have h or more citations; J. E. Hirsch (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 16569-16572. PDF Pubmed; P. Ball (2005) Nature 436, 900)

 

Greater than 1000 citations

Ikura, M., Clore, G.M., Gronenborn, A.M., Zhu, G., Klee, C.B. & Bax, A. (1992) Solution structure of a calmodulin-target peptide complex by multi-dimensional NMR. Science 256, 632-638. pubmed PDF

Brünger, A.T., Adams, P.D., Clore, G.M., DeLano, W.L., Gros, P., Grosse-Kunsteleve, R.W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N.S., Read, R.J., Rice, L.M., Simonson, T. & Warren, G.L. (1998) Crystallography and NMR system (CNS): a new software suite for macromolecular structure determination. Acta Cryst. Series D 54, 901-921. pubmed PDF

Schwieters, C.D., Kuszewski, J., Tjandra, N. & Clore, G.M. (2003) The Xplor-NIH NMR molecular structure determination package. J. Magn. Reson. 160, 66-74. Pubmed PDF

 

500-1000 citations

Nilges, M., Clore, G.M. and Gronenborn, A.M. (1988) Determination of three-dimensional structures of proteins from interproton distance data by hybrid distance geometry-dynamical simulated annealing calculations. FEBS Lett 229, 317-324. pubmed PDF

Nilges, M., Clore, G.M. & Gronenborn, A.M. (1988) Determination of three-dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms. FEBS Letters 239, 129-136. pubmed PDF

Nilges, M., Gronenborn, A.M., Brünger, A.T. & Clore, G.M. (1988) Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints: application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2. Protein Engineering 2, 27-38. pubmed PDF

Marion, D., Driscoll, P.C., Kay, L.E., Wingfield, P.T., Bax, A., Gronenborn, A.M. & Clore, G.M. (1989) Overcoming the overlap problem in the assignment of 1H-NMR spectra of larger proteins using three-dimensional heteronuclear 1H-15N Hartmann-Hahn and nuclear Overhauser - multiple quantum coherence spectroscopy: application to interleukin-1b. Biochemistry 28, 6150-6156. pubmed PDF

Clore, G.M., Szabo, A., Bax, A., Kay, L.E., Driscoll, P.C. & Gronenborn, A.M. (1990) Deviations from the simple two parameter model free approach to the interpretation of 15N nuclear magnetic relaxation of proteins. J. Am. Chem. Soc. 112, 4989-4991. PDF

Clore, G.M., Driscoll, P.C., Wingfield, P.T. & Gronenborn, A.M. (1990) Analysis of backbone dynamics of interleukin-1b using two-dimensional inverse detected heteronuclear 15N-1H NMR spectroscopy. Biochemistry 29, 7387-7401. pubmed PDF

Bax, A., Clore, G.M. & Gronenborn, A.M. (1990) 1H-1H correlation via isotropic mixing of 13C magnetization: a new three-dimensional approach for assigning 1H and 13C spectra of 13C-enriched proteins. J. Magn. Reson. 88, 425-431. PDF

Garrett, D.S., Powers, R., Gronenborn, A.M. & Clore, G.M. (1991) A common sense approach to peak picking two-, three- and four-dimensional spectra using automatic computer analysis of contour diagrams. J. Magn. Reson. 95, 214-220. PDF

Gronenborn, A.M., Filpula, D.R., Essig, N.Z., Achari, A., Whitlow, M., Wingfield, P.T. & Clore, G.M. (1991) A novel highly stable fold of the immunoglobulin binding domain of Streptococcal protein G. Science 253, 657-661. pubmed PDF

 

200-500 citations

Clore, G.M. & Gronenborn, A.M. (1982) Theory and applications of the transferred nuclear Overhauser effect to the study of the conformations of small ligands bound to proteins. J. Magn. Reson. 48, 402-417. PDF

Clore, G.M. & Gronenborn, A.M. (1983) Theory of the time dependent transferred nuclear Overhauser effect: application to the structural analysis of ligand-protein complexes in solution. J. Magn. Reson. 53, 423-442. PDF

Clore, G.M., Gronenborn, A.M., Brunger, A.T. & Karplus, M. (1985) The solution conformation of a heptadecapeptide comprising the DNA binding helix F of the cyclic AMP receptor protein of Escherichia coli: combined use of 1H-nuclear magnetic resonance and restrained molecular dynamics. J. Mol. Biol. 186, 435-455. pubmed PDF

Brunger, A.T., Clore, G.M., Gronenborn, A.M. & Karplus, M. (1986) Three-dimensional structures of proteins determined by molecular dynamics with interproton distance restraints: application to crambin. Proc. Natl. Acad. Sci. U.S.A. 83, 3801-3805. pubmed PDF

Clore, G.M., Brunger, A.T., Karplus, M. & Gronenborn, A.M. (1986) Application of molecular dynamics with interproton distance restraints to three-dimensional protein structure determination: a model study of crambin. J. Mol. Biol. 191, 523-551. pubmed PDF

Clore, G.M., Nilges, M., Sukumaran, D.K., Brunger, A.T., Karplus, M. & Gronenborn, A.M. (1986) The three-dimensional structure of a1-purothionin in solution: combined use of nuclear magnetic resonance, distance geometry and restrained molecular dynamics. EMBO J. 5, 2729-2735. PDF

Clore, G.M., Gronenborn, A.M., Nilges, M. & Ryan, C.A. (1987) The three-dimensional structure of potato carboxypeptidase inhibitor in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics. Biochemistry 26, 8012-8023. pubmed PDF

Holak, T.A., Engström, Å, Kraulis, P.J., Lindeberg, G., Bennich, H., Jones, T.A., Gronenborn, A.M. & Clore, G.M. (1988) The solution conformation of the antibacterial peptide cecropin A: a nuclear magnetic resonance and dynamical simulated annealing study. Biochemistry 27, 7620-7629. pubmed PDF

Clore, G.M. & Gronenborn, A.M. (1989) Determination of three-dimensional structures of proteins and nucleic acids in solution by nuclear magnetic resonance spectroscopy. CRC Critical Reviews in Biochemistry and Molecular Biology 24, 479-564. pubmed

Kraulis, P.J., Clore, G.M., Nilges, M., Jones, T.A., Pettersson, G., Knowles, J. & Gronenborn, A.M. (1989) Determination of the three-dimensional solution structure of the C-terminal domain of cellobiohydrolase I from Trichoderma reesei: a study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing. Biochemistry 28, 7241-7257. pubmed PDF

Clore, G.M., Appella, E., Yamada, M., Matsushima, K. & Gronenborn, A.M. (1990) The three-dimensional structure of interleukin-8 in solution. Biochemistry 29, 1689-1696. pubmed PDF

Kay, L.E., Clore, G.M., Bax, A. & Gronenborn, A.M. (1990) Four-dimensional heteronuclear triple resonance NMR spectroscopy of interleukin-1b in solution. Science 249, 411-414. pubmed PDF

Clore, G.M. & Gronenborn, A.M. (1991) Structures of larger proteins in solution: three- and four-dimensional heteronuclear NMR spectroscopy. Science 252, 1390-1399. pubmed PDF

Clore, G.M. & Gronenborn, A.M. (1991) Applications of three- and four-dimensional heteronuclear NMR spectroscopy to protein structure determination. Progr. Nucl. Magn. Reson. Spectroscopy 23, 43-92. PDF

Baldwin, E.T., Weber, I.T., St. Charles, R., Xuan, J.C., Appella, E., Yamada, M., Matsushima, K., Edwards, B.F.P., Clore, G.M., Gronenborn, A.M. & Wlodawer, A. (1991) Crystal structure of interleukin-8: symbiosis of NMR and crystallography. Proc. Natl. Acad. Sci. U.S.A. 88, 502-506. pubmed PDF

Omichinski, J.G., Clore, G.M., Schaad, O., Felsenfeld, G., Trainor, C., Appella, E., Stahl, S.J. & Gronenborn, A.M. (1993) NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science 261, 438-446. pubmed PDF

Clore, G.M., Omichinski, J.G., Sakaguchi, K., Zambrano, N., Sakamoto, H., Appella, E. & Gronenborn, A.M. (1994) High-resolution solution structure of the oligomerization domain of p53 by multi-dimensional NMR. Science 265, 386-391. pubmed PDF

Clore, G.M. & Gronenborn, A.M. (1994) Multidimensional heteronuclear nuclear magnetic resonance of proteins. Meth. Enzymol. 239, 349-363. pubmed PDF

Werner, M.H., Huth, J.R., Gronenborn, A.M. & Clore, G.M. (1995) Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex. Cell 81, 705-714. pubmed PDF

Lodi, P.J., Ernst, J.A., Kuszewski, J., Hickman, A.B., Engelman, A., Craigie, R., Clore, G.M. & Gronenborn, A.M. (1995) Solution structure of the DNA binding domain of HIV-1 integrase. Biochemistry 34, 9826-9833. pubmed PDF

Ernst, J.A., Clubb, R.T., Zhou, H.-X., Gronenborn, A.M. & Clore, G.M. (1995) Demonstration of positionally disordered water within a protein hydrophobic cavity by NMR. Science 267, 1813-1817. pubmed PDF

Huth, J.R., Bewley, C.A., Nissen, M.S., Evans, J.N.S., Reeves, R., Gronenborn, A.M. & Clore, G.M. (1997) The solution structure of an HMG-I(Y)/DNA complex defines a new architectural minor groove binding motif. Nature Sruct. Biol. 4, 657-665. pubmed PDF

Tjandra, N., Omichinski, J.G., Gronenborn, A.M., Clore, G.M. & Bax, A. (1997) Use of dipolar 15N-1H and 13C-1H couplings in the structure determination of magnetically oriented macromolecules in solution. Nature Struct. Biol. 4, 732-738. pubmed PDF

Clore, G.M., Gronenborn, A.M. & Tjandra, N. (1998) Direct refinement against residual dipolar couplings in the presence of rhombicity of unknown magnitude. J. Magn. Reson. 131, 159-162. pubmed PDF

Clore, G.M., Gronenborn, A.M. & Bax, A. (1998) A robust method for determining the magnitude of the fully asymmetric alignment tensor of oriented macromolecules in the absence of structural information. J. Magn. Reson. 133, 216-221. pubmed PDF

Clore, G.M., Starich, M.R., Gronenborn, A.M. (1998) Measurement of residual dipolar couplings of macromolecules aligned in the nematic phase of a colloidal suspension of rod-shaped viruses. J. Am. Chem. Soc. 120, 10571-10572. PDF

Bewley, C.A., Gustafson, K.R., Boyd, M.R., Covell, D.G., Bax, A., Clore, G.M. & Gronenborn, A.M. (1998) Solution structure of cyanovirin-N, a potent HIV-inactivating protein. Nature Struct. Biol. 5, 571-578. pubmed PDF

Caffrey, M., Cai, M., Kaufman, J., Stahl, S.J., Wingfield, P.T., Covell, D.G., Gronenborn, A.M. & Clore, G.M. (1998) Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J. 17, 4572-4584. pubmed PDF

Iwahara, J. & Clore, G.M. (2006) Detecting transient intermediates in macromolecular binding by paramagnetic NMR. Nature 440, 1227-1230. Pubmed PDF Supplementary Information

Tang, C., Iwahara, J. & Clore, G.M. (2006) Visualization of transient encounter complexes in protein-protein association. Nature 444, 383-386. Pubmed PDF Supplementary Material Movie1 Movie2

Schwieters, C.D., Kuszewski, J. & Clore, G.M. (2006) Using Xplor-NIH for NMR molecular structure determination. Progr. NMR Spectroscopy 48, 47-62. PDF

Tang, C., Schwieters, C.D. & Clore, G.M. (2007) Open-to-closed transition in apo maltose-binding protein visualized by paramagnetic NMR. Nature 449, 1078-1082. Pubmed PDF Supplementary Material

Clore, G.M. & Iwahara, J. (2009) Theory, practice and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes. Chem. Rev. 109, 4108-4139. pubmed PDF

 

100-200 Citations

Clore, G.M., Andreasson, L.E., Karlsson, B., Aasa, R. & Malstrom, B.G. (1980) Characterization of the low temperature intermediates of the reaction of fully reduced soluble cytochrome oxidase with oxygen by electron paramagnetic resonance and optical spectroscopy. Biochem. J. 185, 139-154. pubmed PDF

Clore, G.M., Kimber, B.J. & Gronenborn, A.M. (1983) The 1-1 hard pulse: a novel, simple and effective method of water resonance suppression in FT-1H-NMR. J. Magn. Reson. 54, 170-173. PDF

Gronenborn, A.M. & Clore, G.M. (1985) Investigations into the solution structures of short nucleic acid fragments by means of nuclear Overhauser enhancement measurements. Progr. Nucl. Magn. Reson. Spectroscopy 17, 1-32. PDF

Perutz, M.F., Gronenborn, A.M., Clore, G.M., Hogg, J.H. & Shi, T. (1985) The pKa's of two histidines in human haemoglobin, the Bohr effect and the dipole moment of a-helices. J. Mol. Biol. 183, 491-498. pubmed PDF

Clore, G.M. & Gronenborn, A.M. (1985) Assessment of errors involved in the determination of interproton distance ratios and distances by means of one- and two-dimensional NOE measurements. J. Magn. Reson. 61, 158-164. PDF J. Magn. Reson. Exit Disclaimer

Nilsson, L., Clore, G.M., Gronenborn, A.M., Brunger, A.T. & Karplus, M. (1986) Structure refinement of oligonucleotides by molecular dynamics with NOE interproton distance restraints: application to 5'd(CGTACG)2. J. Mol. Biol. 188, 455-475. pubmed PDF

Clore, G.M. & Gronenborn, A.M. (1987) Determination of three-dimensional structures of proteins in solution by nuclear magnetic resonance spectroscopy. Protein Engineering 1, 275-288. pubmed

Bax, A., Sklenar, V., Clore, G.M. & Gronenborn, A.M. (1987) Water suppression in two-dimensional spin-locked NMR experiments using a novel phase cycling procedure. J. Am. Chem. Soc. 109, 6511-6513. PDF

Oschkinat, H., Griesinger, C., Kraulis, P.J., Sørensen, O.W., Ernst, R.R., Gronenborn, A.M. & Clore, G.M. (1988) Three-dimensional NMR spectroscopy of a protein in solution. Nature 332, 374-376. pubmed PDF

Clore, G.M., Sukumaran, D.K., Nilges, M., Zarbock, J. & Gronenborn, A.M. (1987) The conformations of hirudin in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics. EMBO J. 6, 529-537. PDF

Driscoll, P.C., Gronenborn, A.M., Beress, L. & Clore, G.M. (1989) Determination of the three-dimensional structure of the anti-hypertensive and anti-viral protein BDS-I from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing. Biochemistry 28, 2188-2198. pubmed PDF

Folkers, P.J.M., Clore, G.M., Driscoll, P.C., Dodt, J., Köhler, S. & Gronenborn, A.M. (1989) The solution structure of recombinant hirudin and the Lys-47ÆGlu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study. Biochemistry 28, 2601-2617. pubmed PDF

Gronenborn, A.M., Bax, A., Wingfield, P.T. & Clore, G.M. (1989) A powerful method of sequential proton resonance assignment in proteins using relayed 15N-1H multiple quantum coherence spectroscopy. FEBS Letters 243, 93-98. pubmed PDF

Driscoll, P.C., Clore, G.M., Marion, D., Wingfield, P.T. & Gronenborn, A.M. (1990) Complete resonance assignment for the polypeptide backbone of interleukin-1b using three-dimensional heteronuclear NMR spectroscopy. Biochemistry 29, 3542-3556. pubmed PDF

Bax, A., Clore, G.M., Driscoll, P.C., Gronenborn, A.M., Ikura, M. & Kay, L.E. (1990) Practical aspects of proton-carbon-carbon-proton three-dimensional correlation spectroscopy of 13C--labeled proteins. J. Magn. Reson. 87, 620-628. PDF

Clore, G.M., Bax, A., Wingfield, P.T. & Gronenborn, A.M. (1990) Identification and localization of bound internal water in the solution structure of interleukin-1b by heteronuclear three-dimensional 1H rotating frame Overhauser 15N-1H multiple quantum coherence NMR spectroscopy. Biochemistry 29, 5671-5676. pubmed PDF

Clore, G.M., Bax, A., Driscoll, P.C., Wingfield, P.T. & Gronenborn, A.M. (1990) Assignment of the side chain 1H and 13C resonance of interleukin-1b using double and triple resonance heteronuclear three-dimensional NMR spectroscopy. Biochemistry 29, 8172-8184. pubmed PDF

Omichinski, J., Clore, G.M., Appella, E., Sakaguchi, K. & Gronenborn, A.M. (1990) High resolution three-dimensional solution structure of a single zinc finger from a human enhancer binding protein in solution. Biochemistry 29, 9324-9334. pubmed PDF

Ikura, M., Bax, A., Clore, G.M. & Gronenborn, A.M. (1990) Detection of nuclear Overhauser effects between degenerate amide proton resonances by heteronuclear three-dimensional NMR spectroscopy. J. Am. Chem. Soc.112, 9020-9022. PDF

Nilges, M., Clore, G.M. & Gronenborn, A.M. (1990) 1H-NMR stereospecific assignments by conformational database searches. Biopolymers 29, 813-822. pubmed

Clore, G.M., Kay, L.E., Bax, A. & Gronenborn, A.M. (1991) Four dimensional 13C/13C-edited nuclear Overhauser enhancement spectroscopy of a protein in solution: application to interleukin-1b. Biochemistry 30, 12-18. pubmed PDF

Clore, G.M., Wingfield, P.T. & Gronenborn, A.M. (1991) High resolution three dimensional structure of interleukin-1b in solution by three and four dimensional nuclear magnetic resonance spectroscopy. Biochemistry 30, 2315-2323. pubmed PDF

Forman-Kay, J.D., Clore, G.M., Wingfield, P.T. & Gronenborn, A.M. (1991) The high resolution three-dimensional structure of reduced recombinant human thioredoxin in solution. Biochemistry 30, 2685-2698. pubmed PDF

Powers, R., Gronenborn, A.M., Clore, G.M. & Bax, A. (1991) Three-dimensional triple resonance NMR of 13C/15N enriched proteins using constant-time evolution. J. Magn. Reson. 94, 209-213. PDF

Powers, R., Garrett, D.S., March, C.J., Frieden. E.A., Gronenborn, A.M. & Clore, G.M. (1992) Three-dimensional solution structure of human interleukin-4 by multi-dimensional heteronuclear magnetic resonance spectroscopy. Science 256, 1673-1677. pubmed PDF

Chandrasasekhar, I., Clore, G.M., Szabo, A., Gronenborn, A.M. & Brooks, B.R. (1992) A 500 ps molecular dynamics simulation study of interleukin-1b in water: correlation with nuclear magnetic resonance spectroscopy and crystallography. J. Mol. Biol. 226, 239-250. pubmed PDF

Vuister, G.W., Clore, G.M., Gronenborn, A.M., Powers, R., Garrett, D.S., Tschudin, R. & Bax, A. (1993) Increased resolution and improved spectral quality in four-dimensional 13C/13C-separated HMQC-NOE-HMQC spectra using pulsed field gradients. J. Magn. Reson. Series B 101, 210-213. PDF

Varley, P., Gronenborn, A.M., Christensen, H., Wingfield, P.T., Pain, R.H. & Clore, G.M. (1993) Kinetics of folding of the all b-sheet protein interleukin-1b studied by nuclear magnetic resonance, circular dichroism and fluorescence. Science 240, 1110-1113. pubmed PDF

Sakaguchi, K., Zambrano, N., Baldwin, E.T., Shapiro, B.A., Erickson, J.W., J.G. Omichinski, G.M. Clore, A.M. Gronenborn & E. Appella (1993) Identification of a binding site for the human immunodeficiency virus type I nucleocapsid protein. Proc. Natl. Acad. Sci. U.S.A. 90, 5219-5223. pubmed PDF

Powers, R., Garrett, D.S., March, C.J., Frieden, E.A., Gronenborn, A.M. & Clore, G.M. (1993) The high resolution three-dimensional solution structure of human interleukin-4 determined by multi-dimensional heteronuclear magnetic resonance spectroscopy. Biochemistry 32, 6744-6762. pubmed PDF

Clore, G.M., Robien, M.A. & Gronenborn, A.M. (1993) Exploring the limits of precision and accuracy of protein structures determined by nuclear magnetic resonance spectroscopy. J. Mol. Biol. 231, 82-102. pubmed PDF

Omichinski, J.G., Trainor, C., Evans, T., Gronenborn, A.M., Clore, G.M. & Felsenfeld, G. (1993) A small single-'finger' peptide from the erythroid factor GATA-1 binds specifically to DNA as a zinc or iron complex. Proc. Natl. Acad. Sci. U.S.A. 90, 1676-1680. pubmed PDF

Lodi, P.J., Garrett, D.S., Kuszewski, J., Tsang, M.L.S., Weatherbee, J.A., Leonard, W.J., Gronenborn, A.M. & Clore, G.M. (1994) High resolution solution structure of the b chemokine hMIP-1b by multi-dimensional NMR. Science 263, 1762-1767. pubmed PDF

Garrett, D.S., Kuszewski, J., Hancock, T.J., Lodi, P.J., Vuister, G.W., Gronenborn, A.M. & Clore, G.M. (1994) The impact of direct refinement against three-bond HN-CaH coupling constants on protein structure determination by NMR. J. Magn. Reson. Series B 104, 99-103. pubmed PDF

Qin, J., Clore, G.M. & Gronenborn, A.M. (1994) The high resolution three-dimensional solution structure of the oxidized and reduced states of human thioredoxin: delineation of conformational differences between the two redox states. Structure 2, 503-522. pubmed PDF

Werner, M.H., Clore, G.M., Gronenborn, A.M., Kondoh, A. & Fisher, R.J. (1994) Refolding proteins by gel filtration chromatography. FEBS Lett. 345, 125-130. pubmed PDF

Rozwarski, D.A., Gronenborn, A.M., Clore, G.M., Bazan, J.F., Bohm, A., Wlodawer, A., Hatada, M. & Karplus, P.A. (1994) Structural comparison among the short-chain helical cytokines. Structure 2, 159-173. pubmed PDF

Kuszewski, J., Qin, J., Gronenborn, A.M. & Clore, G.M. (1995) The impact of direct refinement against 13Ca and 13Cb chemical shifts on protein structure determination by NMR. J. Magn. Reson Series B 106, 92-96. pubmed PDF

Qin, J., Clore, G.M. Kennedy, W.M.P., Huth, J.R. & Gronenborn, A.M. (1995) Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFkB. Structure 3, 289-297. pubmed PDF

Clore, G.M., Ernst, J., Clubb, R.T., Omichinski, J.G., Kennedy, W.M.P., Sakaguchi, K., Appella, E. & Gronenborn, A.M. (1995) Refined solution structure of the oligomerization domain of the tumour suppressor p53. Nature Struct. Biol. 2, 321-332. pubmed PDF

Makhatadze, G.I., Clore, G.M. & Gronenborn, A.M. (1995) Solvent isotope effect and protein stability. Nature Struct. Biol. 2, 852-855. pubmed PDF

Kuszewski, J., Gronenborn, A.M. & Clore, G.M. (1995) The impact of direct refinement against proton chemical shifts in protein structure determination by NMR. J. Magn. Reson. Series B 107, 293-297. pubmed PDF

Kuszewski, J., Gronenborn, A.M. & Clore, G.M. (1996) Improving the quality of NMR and crystallographic protein structures by means of a conformational database potential derived from structure databases. Protein Science 5, 1067-1080. pubmed PDF

Grzesiek, S., Bax, A., Clore, G.M., Gronenborn, A.M., Hu, J.-H., Kaufman, J., Palmer, I., Stahl, S.J. & Wingfield, P.T. (1996) The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nature Struct. Biol. 3, 340-345. pubmed PDF

Trainor, C.D., Omichinski, J.G., Vandergon, T.L., Gronenborn, A.M., Clore, G.M. & Felsenfeld, G. (1996) A palyndromic regulatory site with vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA binding domain for high affinity interaction. Mol. Cell. Biol. 16, 2238-2247. pubmed PDF

Pedone, P.V., Ghirlando, R., Clore, G.M., Gronenborn, A.M., Felsenfeld, G. & Omichinski, J.G. (1996) The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high affinity DNA binding. Proc. Natl. Acad. Sci. U.S.A. 93, 2822-2826. pubmed PDF

Werner, M.H., Gronenborn, A.M. & Clore, G.M. (1996) Intercalation, DNA kinking and the control of transcription. Science 271, 778-784. pubmed PDF

Cai, M., Zheng, R., Caffrey, M., Craigie, R., Clore, G.M. & Gronenborn, A.M. (1997) Solution structure of the N-terminal zinc binding domain of HIV-1 integrase. Nature Struct. Biol. 4, 567-577. pubmed PDF

Kuszewski, J., Gronenborn, A.M. & Clore, G.M. (1997) Improvements and extensions in the conformational database potential for the refinement of NMR and X-ray structures of proteins and nucleic acids. J. Magn. Reson. 125, 171-177. pubmed PDF

Omichinski, J.G., Pedone, P.V., Felsenfeld, G., Gronenborn, A.M. & Clore, G.M. (1997) The solution structure of a specific GAGA factor/DNA complex reveals a modular binding mode. Nature Struct. Biol. 4, 122-132. pubmed PDF

Tjandra, N., Garrett, D.S., Gronenborn, A.M., Bax, A. & Clore, G.M. (1997) Defining long range order in NMR structure determination from the dependence of heteronuclear relaxation times on rotational diffusion anisotropy. Nature Struct. Biol.4, 443-449. pubmed PDF

Garrett, D.S., Seok, Y.J., Liao, D.I., Peterkofsky, A., Gronenborn, A.M. & Clore, G.M. (1997) Solution structure of the 30 kDa N-terminal domain of Enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system by multidimensional NMR. Biochemistry 36, 2517-2530. pubmed PDF

Clore, G.M. & Gronenborn, A. M. (1998) New methods of structure refinement for macromolecular structure determination by NMR. Proc. Natl. Acad. Sci. U.S.A. 95, 5891-5898. pubmed PDF

Bewley, C.A., Gronenborn, A.M. & Clore, G.M. (1998) Minor-groove binding architectural proteins: structure, function and DNA recognition. Ann. Rev. Biophys. Biomolec. Struct. 27, 105-131. pubmed PDF

Clore, G.M. & Gronenborn, A.M. (1998) Determining structures of large proteins and protein complexes by NMR.Trends in Biotechnology 16, 22-34. pubmed PDF

Cai, M., Huang, Y., Sakaguchi, K., Clore, G.M., Gronenborn, A.M. & Craigie, R. (1998) An efficient and cost-effective isotope labeling protocol for proteins expressed in Escherichia coli. J. Biomol. NMR 11, 97-102. pubmed PDF

Cai, M., Huang, Y., Zheng, R., Wei, S.-Q., Ghirlando, R., Lee, M.S., Craigie, R., Gronenborn, A.M. & Clore, G.M. (1998) Solution structure of the cellular factor BAF responsible for protecting retroviral DNA from autointegration. Nature Struct. Biol. 5, 903-909. pubmed PDF

Garrett, D.S., Seok, Y.-J., Peterkofsky, A., Gronenborn, A.M. & Clore, G.M. (1999) Solution structure of the 40,000 Mr phosphoryl transfer complex between Enzyme I and HPr. Nature Struct. Biol. 6, 166-173. pubmed PDF

Kuszewski, J., Gronenborn, A.M. & Clore, G.M. (1999) Improving the packing and accuracy of NMR structures with a pseudopotential for the radius of gyration. J. Am. Chem. Soc. 121, 2337-2338. PDF

Yang, F., Bewley, C.A., Louis, J.M., Gustafson, K.R., Boyd, M.R., Gronenborn, A.M., Clore, G.M. & Wlodawer, A. (1999) Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping. J. Mol. Biol. 288, 403-412. pubmed PDF

Clore, G.M., Starich, M.R., Bewley, C.A., Cai, M. & Kuszewski, J. (1999) Impact of residual dipolar couplings on the accuracy of NMR structures determined from a minimal number of NOE restraints. J. Am. Chem. Soc. 121, 6513-6514. PDF

Louis, J.M., Clore, G.M. & Gronenborn, A.M. (1999) Regulation of HIV-1 protease: autoprocessing is tightly coupled to protein folding. Nature Struct. Biol. 6, 868-875. pubmed PDF

Yu, B., Blaber, M., Gronenborn, A.M., Clore, G.M. & Caspar, D.L.D. (1999) Disordered water within a hydrophobic cavity visualized by X-ray crystallography. Proc. Natl. Acad. Sci. U.S.A. 96, 103-108. pubmed PDF

Cornilescu, G., Ramirez, B.E., Frank, M.K., Clore, G.M., Gronenborn, A.M. & Bax, A. (1999) Correlation between 3hJNC’ and hydrogen bond length in proteins. J. Am. Chem. Soc. 121, 6275-6279. PDF

Clore, G.M. & Garrett, D.S. (1999) R-factor, Free R and complete cross-validation for dipolar coupling refinement of NMR structures. J. Am. Chem. Soc. 121, 9008-9012. PDF

Clore, G.M. (2000) Accurate and rapid docking of protein-protein complexes on the basis of intermolecular nuclear Overhauser enhancement data and dipolar couplings by rigid body minimization. Proc. Natl. Acad. Sci. U.S.A. 97, 9021-9025. pubmed PDF

Kontaxis, G., Clore, G.M. & Bax, A. (2000) Evaluation of cross-relaxation effects and measurement of one-bond couplings in proteins with short transverse relaxation times. J. Magn. Reson. 143, 184-196. pubmed PDF

Wang, G., Louis, J.M., Sondej, M., Seok, Y.-J., Peterkofsky, A. & Clore, G.M. (2000) Solution structure of the phosphoryl transfer complex between the signal transducing protein HPr and IIAGlucose of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system. EMBO J. 19, 5635-5649. pubmed PDF

Schwieters, C.D. & Clore, G.M. (2001) Internal coordinates for molecular dynamics and minimization in structure determination and refinement. J. Magn. Reson. 152, 288-302. pubmed PDF

Cai, M., Huang, Y., Ghirlando, R., Wilson, K.L., Craigie, R. and Clore, G.M. (2001) Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA. EMBO J. 20, 4399-4407. pubmed PDF

Braddock, D.T., Louis, J.M., Baber, J.L., Levens, D. & Clore, G.M. (2002) Structure and dynamics of KH domains from FBP bound to single stranded DNA. Nature 415, 1051-1056. pubmed PDF Supplementary

Bewley, C.A., Louis, J.M., Ghirlando, R. & Clore, G.M. (2002) Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41. J. Biol. Chem. 277, 14238-14245. pubmed PDF

Williams, D.C., Cai, M. & Clore, G.M. (2004) Molecular basis for synergistic activation by Oct1 and Sox2 revealed from the solution structure of the 42 kDa Oct1·Sox2·Hoxb1-DNA ternary transcription factor complex. J. Biol. Chem. 279, 1449-1457. pubmed PDF

Iwahara, J., Schwieters, C. D., Clore, G. M. (2004) Ensemble approach for NMR structure refinement against 1H paramagnetic relaxation enhancement data arising from a flexible paramagnetic group attached to a macromolecule. J. Am. Chem. Soc. 126, 5879-5896. Pubmed PDF Supplementary Information

Clore, G.M. & Schwieters, C.D. (2004) How much backbone motion in ubiquitin is required to be consistent with dipolar coupling data measured in multiple alignment media as assessed by independent cross-validation. J. Am. Chem. Soc. 126, 2923-2938. pubmed PDF Supplementary Information

Clore, G.M. & Schwieters, C. D. (2004) Amplitudes of protein backbone dynamics and correlated motions in a small a/b protein: correspondence of dipolar coupling and heteronuclear relaxation measurements. Biochemistry 43, 10678-10691. pubmed PDF Supplementary Information

Iwahara, J., Zweckstetter, M. & Clore, G.M. (2006) NMR structural and kinetic characterization of a homeodomain diffusing and hopping on non-specific DNA. Proc. Natl. Acad. Sci. U.S.A. 103, 15062-15067. Pubmed PDF Supplementary Material

Clore, G.M., Tang, C. & Iwahara, J. (2007) Elucidating transient macromolecular interactions using paramagnetic relaxation enhancement. Curr. Op. Struct. Biol. 17, 603-616. pubmed PDF

Iwahara, J., Tang, C. & Clore, G.M. (2007) Practical aspects of 1H transverse paramagnetic relaxation enhancement measurements on macromolecules. J. Magn. Reson. 184, 185-195. pubmed PDF

Fawzi, N.L., Ying, J., Ghirlando, R, Torchia, D.A. & Clore, G.M. (2011) Atomic resolution dynamics on the surface of amyloid ß protofibrils probed by solution NMR. Nature 480, 268-272. pubmed PDF Supplementary Software for fitting DEST data

 

 

 

 

 

 

 

 

 

 

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