A stable version MERA software package can be downloaded below. When downloading software from this website, you are agreeing to our Terms of Use, including the terms that there is no right to privacy on this system, and that the software from this website is not to be redistributed without permission from the authors. The MERA package provides the hardware & OS versions of linux9, and mac (see here for a definition of those hardware & OS versions by the NMRPipe system), and requires multiple Unix programs and other external software packages in order to use all its features and/or to perform it in an efficient way (see details below).

The most common MERA installation procedure on an Unix environment (linux9 and mac) will involve:

mkdir /disk1/MERA

cd /disk1/MERA

wget http://spin.niddk.nih.gov/bax/software/MERA/mera.tZ wget http://spin.niddk.nih.gov/bax/software/MERA/install.com

chmod +x install.com

install.com

./install.com +help

There is also a Web-Based version of MERA which can be used directly without installing MERA. You can access this Web-based system, along with other facilities for manipulating chemical shifts, dipolar couplings, and molecular structures at the Bax Group NMR Server site:

MERA Installation Files

MERA Web Server

Coil Library (Raw)

(Version 1.00 Rev 2015.198.12.12) install.com [size: 6KB] mera.tZ [size: 25MB]

coil_library_2015.tar.Z [size: 4MB]

As input data, the MERA program currently utilizes up to six types of J couplings ( ^{3}J_{HNHα}, ^{3}J_{C'C'}, ^{3}J_{C'Hα}, ^{1}J_{HαCα}, ^{2}J_{CαN} and ^{1}J_{CαN}), for which the Karplus parameters used are listed below: ^{3}J_{HNHα} = 8.83*cos^{2}(φ-60)-1.29*cos(φ-60)+0.20 ^{3}J_{C'C'} = 1.78*cos^{2}(φ)-0.95*cos(φ)+0.46 ^{3}J_{C'Hα} = 3.78*cos^{2}(φ-60)+1.92*cos(φ-60)+1.19 ^{1}J_{HαCα} = A+1.4*sin(ψ+138)-4.1*cos(2*(ψ+138))+1.7*cos(2*(φ+30)) where A = 143.9 for Ala A = 142.8 for Arg A = 144.5 for Asn A = 144.4 for Asp A = 143.5 for Cys A = 142.9 for Gln A = 142.8 for Glu A = 143.9 for His A = 141.7 for Ile A = 142.5 for Leu A = 142.8 for Lys A = 142.8 for Met A = 144.0 for Phe A = 150.1 for Pro A = 143.5 for Ser A = 142.4 for Thr A = 144.1 for Trp A = 144.1 for Tyr A = 141.7 for Val ^{2}J_{CαN} = -1.51*cos(ψ)-0.66*cos^{2}(ψ)+C where C = 8.15 for Ala/Arg/Cys/Gln/Glu/His/Lys/Met/Pro/Trp C = 8.35 for Asn/Asp C = 7.55 for Ile C = 8.05 for Leu/Phe/Tyr C = 7.65 for Ser C = 7.75 for Thr C = 7.65 for Val ^{1}J_{CαN} = 1.7*cos^{2}(ψ)-0.98*cos(ψ)+9.51+offset where offset = 0.2 for Asn offset = 0.1 for Asp offset =-0.1 for Leu offset = 0.1 for Phe/Tyr offset = 0.6 for Ser/Thr offset = 0.1 for Val

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