Dr. Marcel Ottiger

Tel.: 301-496-7902
Fax: 301-496-0825

E-mail: ottiger@speck.niddk.nih.gov

RESEARCH INTERESTS

Structural Biology, Structure Determination with Nuclear Magnetic Resonance
 

EDUCATION

Ph.D. in Biophysics
ETH Zürich, Switzerland, with Prof. Kurt Wüthrich, 1996

Diploma in Biochemistry (B.S./M.S.)
ETH Zürich, Switzerland, 1992
 

PROFESSIONAL EXPERIENCE

Post-Doctoral Fellow
National Institutes of Health, Bethesda, Maryland, USA , since 1996
 

AWARDS AND FELLOWSHIPS

Fellowship by the National Institutes of Health, U.S.A., 1997
Competitive Fellowship by the Swiss National Science Foundation, 1996
 

PUBLICATIONS

Publications from the Bax Group

Previous  Publications:

Ottiger, M., Zerbe, O., Güntert, P. & Wüthrich, K. The NMR solution conformation of unligated human
cyclophilin A. J. Mol. Biol. 272, 64­81 (1997).

Nieba-Axmann, S., Ottiger, M., Wüthrich, K. & Plückthun, A. Multiple cycles of global unfolding of
GroEL-bound cyclophilin A evidenced by NMR. J. Mol. Biol. 271, 818­803 (1997).

Ottiger, M. NMR-Studien über Proteinstruktur und Proteinfaltung: menschliches Cyclophilin A und
Er-2 von Euplotes raikovi. Doktorarbeit, ETH Nr. 11723 (1996).

Zerbe, O., Szyperski, T., Ottiger, M. & Wüthrich, K. 1H-TOCSY-revelayed ct-[13C,1H]-HMQC for aromatic
spin system identification in uniformly 13C labeled proteins. J. Biomol. NMR 7, 99­106 (1996).

Rhyner, J. A., Ottiger, M., Wicki, R., Greenwood, T. M. & Strehler E. E. Structure of the human CALM1
calmodulin gene and identification of two CALM1-revelated pseudogenes CALM1P1 and CALM1P2.
Eur. J. Biochem. 225, 71­82 (1994).

Luginbühl, P., Ottiger, M., Mronga, S. & Wüthrich, K. Structure comparison of the pheromones Er-1,
Er-10 and Er-2 from Euplotes raikovi. Protein Sci. 3, 1537­1546 (1994).

Ottiger, M., Szyperski, T., Luginbühl, P., Ortenzi, C., Luporini, P., Bradshaw, R. A. & Wüthrich, K. The
NMR solution structure of the pheromone Er-2 from the ciliated protozoan Euplotes raikovi. Protein
Sci. 3, 1515­1526 (1994).

Zahn, R., Spitzfaden, C., Ottiger, M., Wüthrich, K. & Plückthun, A. Destabilization of the complete
protein secondary structure on binding to the chaperone GroEL. Nature 368, 261­265 (1994).
 

MISCELLANOUS

Webmaster for the Bax group at the Laboratory of Chemical Physics, NIDDK, NIH, 1998-present
Webmaster for the Wüthrich group at the Institute for Molecular Biology and Biophysics, ETH Zurich, 1995-1996