Dr. Marcel Ottiger

National Institutes of Health
Building 5, Room B1-28
9000 Rockville Pike
Bethesda, MD 20892-0520

Tel.: 301-496-7902
Fax: 301-496-0825

E-mail: ottiger@speck.niddk.nih.gov


Structural Biology, Structure Determination with Nuclear Magnetic Resonance


Ph.D. in Biophysics
ETH Zürich, Switzerland, with Prof. Kurt Wüthrich, 1996

Diploma in Biochemistry (B.S./M.S.)
ETH Zürich, Switzerland, 1992


Post-Doctoral Fellow
National Institutes of Health, Bethesda, Maryland, USA , since 1996


Fellowship by the National Institutes of Health, U.S.A., 1997
Competitive Fellowship by the Swiss National Science Foundation, 1996


Publications from the Bax Group

Previous  Publications:

Ottiger, M., Zerbe, O., Güntert, P. & Wüthrich, K. The NMR solution conformation of unligated human
cyclophilin A. J. Mol. Biol. 272, 64­81 (1997).

Nieba-Axmann, S., Ottiger, M., Wüthrich, K. & Plückthun, A. Multiple cycles of global unfolding of
GroEL-bound cyclophilin A evidenced by NMR. J. Mol. Biol. 271, 818­803 (1997).

Ottiger, M. NMR-Studien über Proteinstruktur und Proteinfaltung: menschliches Cyclophilin A und
Er-2 von Euplotes raikovi. Doktorarbeit, ETH Nr. 11723 (1996).

Zerbe, O., Szyperski, T., Ottiger, M. & Wüthrich, K. 1H-TOCSY-revelayed ct-[13C,1H]-HMQC for aromatic
spin system identification in uniformly 13C labeled proteins. J. Biomol. NMR 7, 99­106 (1996).

Rhyner, J. A., Ottiger, M., Wicki, R., Greenwood, T. M. & Strehler E. E. Structure of the human CALM1
calmodulin gene and identification of two CALM1-revelated pseudogenes CALM1P1 and CALM1P2.
Eur. J. Biochem. 225, 71­82 (1994).

Luginbühl, P., Ottiger, M., Mronga, S. & Wüthrich, K. Structure comparison of the pheromones Er-1,
Er-10 and Er-2 from Euplotes raikovi. Protein Sci. 3, 1537­1546 (1994).

Ottiger, M., Szyperski, T., Luginbühl, P., Ortenzi, C., Luporini, P., Bradshaw, R. A. & Wüthrich, K. The
NMR solution structure of the pheromone Er-2 from the ciliated protozoan Euplotes raikovi. Protein
Sci. 3, 1515­1526 (1994).

Zahn, R., Spitzfaden, C., Ottiger, M., Wüthrich, K. & Plückthun, A. Destabilization of the complete
protein secondary structure on binding to the chaperone GroEL. Nature 368, 261­265 (1994).


Webmaster for the Bax group at the Laboratory of Chemical Physics, NIDDK, NIH, 1998-present
Webmaster for the Wüthrich group at the Institute for Molecular Biology and Biophysics, ETH Zurich, 1995-1996

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