Dr. James Jeiwen Chou


National Institutes of Health
Building 5, Room B1-27
9000 Rockville Pike
Bethesda, MD 20892-0520

Tel.: 301-496-7098
Fax: 301-496-0825

E-mail: jjchou@speck.niddk.nih.gov


All aspects of structural biology


Ph.D., Biophysics 1999
Harvard University
Thesis Advisor: Gerhard Wagner
Thesis Title: Unravelling Structural Motifs Involved in Apoptotic Signaling Pathways

B.S., Physics 1994
University of Michigan, Ann Arbor


Post-Doctoral Fellow
National Institutes of Health, Bethesda, Maryland, USA , 1999-present


Publications from the Bax Group
Previous  Publications:

J.J. Chou and C. Zhang: A Joint Prediction of the Folding Types of 1490 Human Proteins from their Genetic Codons, J. theor. Biol., 161, 251-262 (1993)

J.J. Chou: A Formulation for Correlating Properties of Peptides and Its Application to Predicting Human Immunodeficiency Virus Protease-Cleavable Sites in Proteins, Biopolymers, 33, 1405-1414 (1993)

I.W. Althaus, J.J. Chou, A.J. Gonzales, M.R. Deibel, K.C. Chou, F.J. Kezdy, D.L. Romero, J.R. Palmer, R.C. Thomas, P.A. Aristoff, W.G. Tarpley, and F. Reusser: Kinetic Studies with the Non-nucleoside HIV-1 Reverse Transcriptase Inhibitor U-88204E, Biochemistry, 32, 6548-6554 (1993)

J.J. Chou and E.I. Shakhnovich: A Study on Local-Global Cooperativity in Protein Collapse, J. Phys. Chem. B, 103, 2535-2542 (1999)

J.J. Chou, H. Matsuo, H. Duan, and G. Wagner: Solution Structure of the RAIDD CARD Domain and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment, Cell, 94, 171-180 (1998)

J.J. Chou, H. Li, G.S. Salvesen, J. Yuan, and G. Wagner: Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling, Cell, 96, 615-624 (1999)

P. Zhou, J.J. Chou, R.S. Olea, J. Yuan, and G. Wagner: Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction, Proc. Natl. Acad. Sci., 96, 11265-11270 (1999)

A.A. Lugovskoy, P. Zhou, J.J. Chou, J.S. McCarty, P. Li, and G. Wagner: Solution Structure of the CIDE-N Domain of CIDE-B and a Model for CIDE-N/CIDE-N Interactions in the DNA Fragmentation Pathway of Apoptosis, Cell, 99, 747-755 (1999)

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