Dr. Beat Rolf Vögeli

National Institutes of Health
Building 5, Room B1-27
9000 Rockville Pike
Bethesda, MD 20892-0520

Tel: (+1)-301-451-7234
E-mail: vogelib@niddk.nih.gov
E-mail: beatvoegeli@hotmail.com

Beat

Research Interests: Methodology and Application in Liquid State NMR

Development of liquid state NMR methods for a complete description of protein dynamics: Although state-of-the-art methods characterize motions of isolated bond vectors, concerted dynamics of larger spin networks is still poorly understood.

Design of pulse sequences (TROSY experiments, selection of individual transitions, 13C-detection spectroscopy): Large molecular tumbling times severely restrict the applicability of liquid state NMR to important systems such as membrane proteins or large proteins.

Structural and Dynamical Studies on a glycoprotein involved in the immunoevasion of a cytomegalovirus.

Education

Ph. D. in Natural Sciences (Dr. sc. nat.) at the Institut für Physikalische Chemie, ETH Zürich, 2005

Diploma in Physics (Dipl. phys. ETH) at ETH Zürich (Biophysics and Particle Physics), 2001

Swiss Federal Graduation Diploma, Humanistic Type (Eidgenössische Matura Typus B), 1996

Professional Experience

Post-Doctoral Associate
Laboratory of Chemical Physics, National Institute of Diabetes, Digestive & Kidney Diseases (NIDDK) of the National Institutes of Health (NIH), Bethesda, Maryland, USA in the Research Group of Dr. A. Bax, 2005-present.

Research Fellow
Institut für Physikalische Chemie, ETH Zürich, Switzerland in the Research Group of Prof. K. Pervushin, 2001-2005

Institute of Molecular Biology and Biophysics, ETH Zürich, Switzerland in the Research Group of Prof. K. Wüthrich, 2000-2001

Industrial Collaboration
Bruker BioSpin AG, Fällanden, Switzerland 2002-2005

Teaching
Advanced Techniques in Solution State NMR of Biomolecules, ETH Z
ürich, 2005

Physical Chemistry for Biologists, Chemists and Pharmacists, ETH Zürich, 2001-2005

Publications

* equal contribution

Beat Vögeli, Lishan Yao and Ad Bax, Protein Backbone Motion Viewed by Intraresidue and Sequential HN-Ha Residual Dipolar Couplings, 2008, J. Biomol. NMR, in press.

Lishan Yao, Beat Vögeli, Dennis Torchia and Ad Bax, Simultaneous NMR Study of Protein Structure and Dynamics Using Conservative Mutagenesis, 2008, J. Phys. Chem. B, online.

Konstantin Pervushin, Katherina Vamvaca*, Beat Vögeli* and Donald Hilvert, Structure and Dynamics of an Enzymatically Active Molten Globule, 2007, Nat. Struct. Mol. Biol, 14, 1202-1206.

Beat Vögeli, Jinfa Ying, Alexander Grishaev and Ad Bax, Limits on Variations in Protein Backbone Dynamics from Precise Measurements of Scalar Couplings, 2007, J. Am. Chem. Soc., 129, 9377-9385.

Kaifeng Hu, Beat Vögeli and G. Marius Clore, Spin-State Selective Carbon-Detected HNCO with TROSY Optimization in All Dimensions and Double Echo-Antiecho Sensitivity Enhancement in Both Indirect Dimensions, 2007, J. Am. Chem. Soc., 129, 5484-5491.

Kaifeng Hu*, Beat Vögeli* and G. Marius Clore, 13C-Detected HN(CA)C and HMCMC Experiments Using a Single Methyl-Reprotonated Sample for Unambiguous Methyl Resonance Assignment, 2006, J. Biomol. NMR, 36, 259-266.

Kaifeng Hu*, Beat Vögeli* and G. Marius Clore, Interference between Transverse Cross-Correlated Relaxation and Longitudinal Relaxation Affects Apparent J-Coupling and Transverse Cross-Correlated Relaxation, 2006, Chem. Phys. Lett., 423, 123-125.

Donghan Lee, Beat Vögeli and Konstantin Pervushin, Detection of C',CA Correlations in Proteins Using a New Time- and Sensitivity-Optimal Experiment, 2005, J. Biomol. NMR, 31, 273-278.

Beat Vögeli, Towards Structure and Dynamics of Large and Dynamically Disordered Biomacromolecules: New Methods in Solution NMR Spectroscopy, 2005, Ph.D. Thesis, ETH Zürich, Diss. ETH No. 15993 (http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15993).

Kaifeng Hu, Beat Vögeli and Konstantin Pervushin, Side-Chain H and C Resonance Assignment in Protonated / Partially Deuterated Proteins Using a New 3D 13C-Detected HCC-TOCSY, 2005, J. Magn. Reson., 174, 200-208.

Beat Vögeli, Helena Kovacs and Konstantin Pervushin, Simultaneous 1H- or 2H-, 15N- and Multiple-Band-Selective 13C-Decoupling during Acquisition in 13C-Detected Experiments with Proteins and Oligonucleotides, 2005, J. Biomol. NMR, 31, 1-9.

Konstantin Pervushin, Beat Vögeli, Tim Heinz and Philippe Hünenberger, Measuring 1H-1H and 1H-13C RDCs in Methyl Groups: Example of Pulse Sequences with Numerically Optimized Coherence Transfer Schemes, 2005, J. Magn. Reson., 172, 36-47.

Editors' Choice: Highlights of the Recent Literature, Biochemistry: One Size Fits Many, 2004, Science, 305, 5691-5691.

Katherina Vamvaca, Beat Vögeli, Peter Kast, Konstantin Pervushin and Donald Hilvert, An Enzymatic Molten Globule: Efficient Coupling of Folding and Catalysis, 2004, Proc. Natl. Acad. Sci. USA, 101, 12860-12864.

Katherina Vamvaca, Beat Vögeli, Peter Kast, Konstantin Pervushin and Donald Hilvert, Enzymatic Catalysis: Taking "Induced Fit" to Extremes, 2004, Protein Sci., 13, 106-106 170 Suppl. 1.

Beat Vögeli, Helena Kovacs and Konstantin Pervushin, Measurements of Side-Chain 13C- 13C Residual Dipolar Couplings in Uniformly Deuterated Proteins, 2004, J. Am. Chem. Soc., 126, 2414-2420.

Konstantin Pervushin and Beat Vögeli, Observation of Individual Transitions in Magnetically Equivalent Spin Systems, 2003, J. Am. Chem. Soc., 125, 9566-9567.

Beat Vögeli and Konstantin Pervushin, TROSY Experiment for Refinement of Backbone psi and phi by Simultaneous Measurements of Cross-Correlated Relaxation Rates and 3,4JHaHN Coupling Constants, 2002, J. Biomol. NMR, 24, 291-300.

Konstantin Pervushin, Beat Vögeli and Alexander Eletsky, Longitudinal 1H Relaxation Optimization in TROSY NMR Spectroscopy, 2002, J. Am. Chem. Soc., 124, 12898-12902.

Beat Vögeli, Roland Riek (Supervisor) and Kurt Wüthrich (Supervisor), NMR Solution Structure of the Fragments of the Human Prion Protein hPrP(121-226) and hPrP(130-230), 2001, Diploma Thesis, ETH Zürich.

Talks

Institut für Physikalische Chemie, ETH Zürich, 2007

Colloquium of the Institut für Physikalische Chemie, ETH Zürich, 2004

Group Representative for Evaluation Committee, ETH Zürich, 2004

Lecture Summer School Otocec 2003, Slovenia

EENC European Experimental Nuclear Magnetic Resonance Conference 2002 Prague

Poster Presentations

Protein Aggregation and Amyloid Formation in Systemic and Neurodegenerative Diseases: Physical, Molecular and Biological Approaches, EPFL, Lausanne, Switzerland, 2005

Joining Forces Symposium, ETH Zürich, Switzerland 2004

Protein Society Meeting, San Diego, USA, 2004

International Greek Biotechnology Forum, Athens, Greece, 2004

EMBO Young Investigator Programme, EMBL Heidelberg, Germany, 2004

Biologie-Departement Symposium Davos, Switzerland, 2004

ENC 44th Experimental Nuclear Magnetic Resonance Conference, Savannah, USA, 2003

EENC European Experimental Nuclear Magnetic Resonance Conference, Prague, 2002

Fünfte Igler NMR Tage, Austria, 2002

Awards and Fellowships

Competitive Fellowship by the Swiss National Science Foundation, 2005