A Server Program for Hydrogen Exchange Rate
Estimation
The program does not collect any usr information or user input data.
Neither the author of this program, YuZhu Zhang, nor any party related to hosting the SPHERE program
will be responsible for any damage that may result from using this program.
The author retains the right to modify or remove the
program without notice.
If you use SPHERE to produce data for publication, Please advertise this page and reference ref. 1 on the SPHERE help page, where an early version of the Fortran Code for this program can be found.
Also, I highly recomment referencing ref. 2 on the
SPHERE help
page
where most of the information this program based on can be found.
Exchange in:D2O H2O
pH meter reading:
Temperature: oC
Reference Data from:
Poly D-L Alanine
Alanine in Oligo-peptide
Are the terminals blocked?
N-Term: YesNo
C-Term: Yes No
Default pKa
His:
Glu:
Asp:
N-term.:
C-term.:
Default activation energies Eas, (kcal/mol):
Acid EaH:
Base EaOH:
General EaG:
Are all cysteines involved in disulfide bonds?
Yes No
If not, Type in the residue number of the reduced
Cysteine(s), separated by a space:
Are there any cis Proline(s) in the structure?
Yes No
If yes, Type in the residue number of the cis Proline(s),
separated by a space:
Enter your sequence (or copy & paste) below: (one-letter code only)