Structure-based design of gp41 targeted HIV-1 envelope-mediated cell fusion inhibitors II

Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion

 

 

 

Design of covalently linked trimers derived from the N-terminal helices of gp41

 

Covalently linked trimers derived from the N-terminal trimeric coiled-coil of gp41 are highly potent fusion inhibitors which target the expsoed C-region in the pre-hirpin intermediate state

 

A tightly binding antibody fraction purified from polyclonal antibodies directed against N35_CCG-N13 is a very potent inhibitor of fusion and is targeted against the internal trimeric coiled-coil of gp41 in the pre-hairpin intermediate state.

 

 

 

Louis, J.M., Nesheiwat, I., Chang, L.C., Clore, G.M. & Bewley, C.A. (2003) Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion. J. Biol. Chem. e-pub ahead of print. Pubmed PDF

 

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