Frank Delaglio, Ph.D.(Contractor)National Institutes of Health NIDDK, LCP Building 5, Room B1-35 5 Center Dr MSC 0505 Bethesda, MD 20892-0505 Tel.: 301-496-1207
E-mail: delaglio@nih.gov |
|
PROFESSIONAL INTERESTS
Scientific software development for commercial and research applications,
emphasizing NMR biomolecular structure determination, drug discovery,
and proteomics.
PROFESSIONAL EXPERIENCE
1991-Current
Special Expert (subsequently Staff Scientist, currently Contractor)
National Institutes of Health, Section on Biophysical NMR, NIDDK LCP
Principal software scientist for the Bax group. Primary research areas include relationship between NMR observables and protein structure, multidimensional signal processing, automated spectral analysis, high-precision spectral feature measurement, parallel processing, and support of NMR structure calculation.
Current research emphasizes novel approaches to improve the speed and effectiveness of protein structure determination using homology based on NMR parameters such as dipolar couplings and chemical shifts.
1991-Current
Software Science Consultant
Software applications consultant to numerous leading pharmaceutical companies emphasizing structure-based drug design.
Scientific software advisor to companies developing and supporting spectral analysis and imaging software.
Software advisor for the Lund University Hospital Image Digitization Project (Sweden), a medical image display and archive project serving 290 clinicians performing 200,000 imaging examinations annually.
Developed targeted applications for visualization and analysis of multivariate infrared spectroscopic images.
1985-1991
Product Manager, New Methods Research, Inc. (a 1989 Inc 500 Small Company).
As leader of a four member group, designed and implemented NMR2, a
commercially successful software package for Two-Dimensional NMR analysis.
1983-1985
Senior Programmer Analyst, Syracuse University
Designed software modules for NMR spectral processing and analysis.
Summers 1982 and 1983
Physical Chemistry Research Assistant, Syracuse University
Developed mathematical models and software for interpretation of Small-Angle
X-ray Scattering data.
1982-1983
General Chemistry Teaching Assistant, Syracuse University
PROFESSIONAL SKILLS
Effective public speaker.
Managed teams of Ph.D. scientists and graduate level programmers.
Skilled in all aspects of scientific software development.
Well versed in NMR, signal processing techniques, and numerical methods.
Extensive programming experience, C, HTML, X11, Tk/TCL, etc.
INVITED PRESENTATIONS
2005 and Pending
Protein Chemistry School, Copenhagen Denmark
NANUC NMR Course, Edmunton Canada
EMBO NMR Course, Basel Switzerland
2004
LAS NMR Workshops, Japan
University of California, Irvine
Yale Medical School
Harvard Medical School
Texas A+M University
2003
New York Structural Biology Center
State University of New York, Stony Brook
EMBO NMR Course, Heidelberg Germany
NANUC NMR Course, Edmonton Canada
University of California, Irvine
LAS NMR Workshops, Japan
2002
LAS NMR Workshops, Japan
2001
CCPN Meeting, Cambridge, England
Genomic Science Center Symposium, Japan
Yokohama NMR Structural Biology Symposium
CCPN Meeting, Edinburg Scotland
Washington Area NMR Group (WANG)
LAS NMR Workshops, Japan
2000
Nalorac Symposium (ENC)
LAS NMR Workshops, Japan
Texas A+M University
Ontario Cancer Institute
Pacific Northwest Lab Structural Genomics Workshop
1999
University of Georgia
University of Virginia
CHI Frontiers of NMR
Osaka University
Tokyo University
Nalorac Symposium (ENC)
Keystone Symposium, Frontiers of NMR
Gordon Conference, Computational NMR
1998
Yale University, Yale Magnetic Resonance Seminars
Center for Advanced Research in Biotechnology, Maryland
LAS NMR Workshops, Japan
1997
Weizmann Institute of Science, Israel
Tsukuba International NMR Conference, Japan
LAS NMR Workshops, Japan
Karolinska Medical Research Institute, Sweden
1996
American Chemical Society NYC Area NMR Meeting
Ontario Cancer Institute, Canada
University of Maryland School of Medicine
Tsukuba International NMR Conference, Japan
1995
Japan Young NMR Scientists Conference
LAS NMR Workshops, Japan
Johns-Hopkins University Department of Chemistry
Tsukuba International NMR Conference, Japan
1994
Japan Young NMR Scientists Conference
LAS NMR Workshops, Japan
Sloan-Kettering Cancer Center
Karolinska Medical Research Institute, Sweden
Glaxo US
1993
Protein Engineering Centers of Excellence, Canada
LAS NMR Workshops, Japan
Ontario Cancer Institute, Canada
1992
LAS NMR Workshops, Japan
Ontario Cancer Institute, Canada
1991
JTC NMR Workshops, Japan
Astra AB, Sweden
1990
NATO Advanced Research Workshop, Italy
EDUCATION
Syracuse University, 1979-1984
B.A., Dept of Chemistry
Osaka University, 2000-2001
Ph.D., Dept of Pharmaceutical Sciences
PUBLICATIONS
Publications from the Bax Group
Other publications:
1. A structural model for Alzheimer's beta-amyloid fibrils based on experimental constraints from solid state NMR, Petkova A.T., Ishii Y., Balbach J.J., Antzutkin O.N., Leapman R.D., Delaglio F., Tycko R. P. Natl. Acad. Sci. USA 99 (26), 16742-16747 (2002).
2. Multivariate Data Analysis for Pattern Recognition in 2D NMR, H. Grahn, F. Delaglio, M.A. Delsuc and G.C. Levy, J. Magn. Reson., 77, 294-307 (1988).
3. Toward a Computer Assisted Analysis of NOESY Spectra: A Multivariate Data Analysis of an RNA NOESY Spectrum, H. Grahn, U. Edlund, Y.T. van den Hoogen, C. Altona, F. Delaglio, M.W. Roggenbuck, P.N. Borer, J. Biomol. Struct. Dyn., 6, 1135-1150 (1989).
4. Data Analysis of Multivariate Magnetic Resonance Images, H. Grahn, N.M. Szeverenyi, M.W. Roggenbuck, F. Delaglio, P. Geladi, Chemometrics and Intelligent Laboratory Systems, 5, 311-322 (1989).
5. NMR2: A Powerful Software System for Processing Multi-Dimensional NMR Data, G.C. Levy, F. Delaglio, A. Macur and J. Begemann, Computer Enhanced Spectroscopy, 3, 1-12 (1986).
6. A Segmentation Technique for Automated Contour Selection in 2D NMR Spectroscopy, P. Sole, F. Delaglio, G.C. Levy, J. Magn. Reson., 80, 517-519 (1988).
7. Quantitative Analysis of Multivariate Magnetic Resonance Images, P. Sole, F. Delaglio, A. Macur, and G.C. Levy, International Labmate, 14 (1988).
8. Interactive Image Processing for NMR Imaging and Spectroscopy, P. Sole, F. Delaglio, A. Macur, and G.C. Levy, American Laboratory, August 1988.
9. Artificial Intelligence, Logic Programming, and Statistics in Magnetic Resonance Imaging and Spectroscopic Analysis, T.J. Harner, G.C. Levy, E.J. Dudewicz, F. Delaglio, and A. Kumar, Chapter 26, Artificial Intelligence Applications in Chemistry, ed. T.H. Price, B.A. Hohne, ACS Symposium Series 306, 337-349 (1986).
10. A Correlated-Cell Model for Small-Angle X-Ray Scattering of Amorphous Systems, F. Delaglio, J. Goodisman and H. Brumberger, J. Catalysis, 99, 383-390 (1986).
11. Analysis of Slit-Distorted Small-Angle X-Ray Scattering Intensities Without Desmearing, J. Goodisman, F. Delaglio and H. Brumberger, J. App. Cryst., 19, 243-245 (1986).
12. Sintering of Pt/Al2O3 From Continuous Small-Angle X-Ray Scattering, H. Brumberger, Y.C. Chang, M.G. Phillips, F. Delaglio and J. Goodisman, J. Catalysis, 97 (1986).